Associate Professor Jonathan Arthur

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Themes | Research interests | Grants | Keywords

Themes

Infection and Immunological Conditions

Research interests

Proteomic bioinformatics: Proteomics depends critically on the ability to be able to identify and then characterize the thousands of proteins whose expression makes up the proteome of a particular individual at a particular time. The vast quantity of data generated by typical proteomic projects requires appropriate bioinformatics algorithms to enable this. Jonathan is interested in developing novel algorithms for the robust, accurate, and efficient identification and characterization of proteins using mass spectrometry.

Multiple sclerosis: Multiple sclerosis is an inflammatory and demyelinating autoimmune disorder of the central nervous system. It is the most common chronic neurological disease affecting young adults and affects approximately 15,000 people throughout Australia. Jonathan is interested in applying proteomics and bioinformatics to address ongoing questions regarding the aetiology, diagnosis, prognosis, and molecular basis of this disease.

Current national competitive grants*

2009

Statistical and computational methods using a multiscale approach for protein identification and quantification
Yang J, Raimondo M, Arthur J
ARC Discovery Project ($260,000 over 3 years)

2006

Molecular response to interferon beta treatment in multiple sclerosis
Arthur J, Sedger L, Booth D, Stewart G, Heard R, McKay F
ARC Linkage Project ($411,000 over 4 years)

* Grants administered through the University of Sydney

Keywords

Proteomics; Multiple sclerosis; Computational biology; Bioinformatics