Dr James Guy Lyons

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Themes | Research interests | Grants | Keywords

Themes

Cancer; Infection and Immunological Conditions

Research interests

Dr Lyons' research aims to determine the cellular and molecular mechanisms by which oncogenes and tumour suppressor genes contribute to the formation of squamous cell carcinomas of the skin and of the head and neck region, two of the most common sites for cancer. Of particular interest are genes involved in the progression from benign tumours, which are non-invasive and usually easily treated, to malignant tumours, which spread invasively from the site of origin and are difficult to treat successfully. This research encompasses a broad range of molecular and cell biological methods and analyses, including cell culture, plasmid and virus vector construction, gene expression analysis, small animal handling and microscopy. Both in vivo and in vitro models for squamous cell carcinogenesis are established in the laboratory.

Current national competitive grants*

2010

Brm and Brg-1 protect from ultraviolet radiation-induced skin and ocular damage
Halliday G, Lyons J, Di Girolamo N, Moloney F, Lee C
NHMRC Project Grant ($535,500 over 3 years)

* Grants administered through the University of Sydney

Keywords

Genetic processes; Cancer; Virus diseases; Head and neck cancer; Cell biology