Professor Chris Liddle
|
Professor of Clinical Pharmacology & Hepatology
C24 - Westmead Hospital |
|
||||||||
On this page
Research interests
Over the past decade Chris' main area of research has been in the functional genomics of human drug metabolism and adaptive responses to toxic xenobiotic (foreign) and endobiotic (endogenous) chemical compounds. This work has culminated in the recent discovery of mechanisms that lead to important drug interactions, a finding that will impact significantly on future therapeutic drug development. An extension of this work is to understand how the liver protects itself from toxic damage, as occurs in liver diseases where the flow of bile is obstructed (cholestatic liver diseases). This work has led to several patents as well as highly cited publications. He also has an interest in advanced information technology systems in the fields of medical research and clinical medicine and is presently Associate Dean for Information Technology within the Faculty of Medicine.
Current national competitive grants*
2008
Function of Vitamin D Receptor in Hepatic Non-Parenchymal Cells
Liddle C, Downes M
NHMRC Project Grant ($488,750 over 3 years)
2006
Role of nuclear receptors in haptic injury and fibrogenesis
Liddle C, London R, Downes M
NHMRC Project ($434,750 over 3 years)
* Grants administered through the University of Sydney